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In order to protect address space integrity, z/OS will not allow address spaces to be reusable if they make use of certain types of PCs, or if they connect to other address spaces which make use of those PCs. The MQ address spaces makes of use of these types of PCs as part of its core function so we can't implement this idea I am afraid.
Some details on why this protection is necessary is here: https://www.ibm.com/docs/en/zos/2.1.0?topic=ra-coding-cross-memory-services-avoid-loss-asids-from-reuse
As you say one option here is to use client mode connections to connect from WAS to MQ. Another option would be to stop the WAS applications over night but leave the WAS server running.